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In PWA mice, treatment with GLP1/E caused a significant decrease in body weight (10%) and fat mass (50%), as well as a reduction in food intake and substantial improvement in glucose metabolism and insulin sensitivity, denoted by ITT and HOMA-IR, as well as serum glucose, insulin (Fig

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212 Further, increased expression and low methylation of CDKN1A and PDE7B genes in T2DM can lead to impaired insulin release that is stimulated by glucose in T2DM patients

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