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Circadian gene expression The circadian clock is not just about melatonin levels

Acknowledgements The author expresses his profound gratitude to Brandy N

Holland-FischerPGronbaekHSandahlTDMoestrupSKRiggioORidolaLet al

For the reporter assay, cells were transfected with a Gaussia luciferase (GLUC) plasmid containing either the human SIRT1 promoter (HRPM35661-PG02, Genecopoeia, USA) or the mouse HK2 promoter (MPRM42494-PG02, Genecopoeia) sequence, along with a Renilla luciferase plasmid

(5) Taken together, these observations suggest that AOD9604 may act through multiple coordinated mechanisms to support fat metabolism, especially in obesity-related laboratory scenarios robustly