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However, pathological modifications oxidation, glycation, citrullination, carbonylation, and enzymatic carboxyethylation of cysteine (linked to ankylosing spondylitis) can render self-proteins immunogenic, driving autoimmune disease by presenting chemically altered peptides to the immune system as foreign antigens.

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Sensory nerve damage produces the symptoms most people associate with neuropathy: numbness, tingling, burning pain, pins-and-needles sensations, and hypersensitivity to touch