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However, to date, this hypothesis remains inconclusive because mice lacking GLP-1 receptors (GLP-1Rs) responded similarly to controls after vertical sleeve gastrectomy

This realization set the stage for two parallel strategies that unfolded in the 1990s and 2000s: (1) development of injectable GLP-1 analogues resistant to degradation, and (2) development of DPP-4 inhibitors to protect and elevate native GLP-1 levels ( [44] )

Coverage may require confirmation of type 2 diabetes and other clinical criteria