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Furthermore, animal research has found that extremely high doses of alpha-lipoic acid may promote oxidation, alter liver enzymes, and place strain on liver and breast tissue (38, To date, very few studies have looked at the safety of alpha-lipoic acid in children and pregnant women

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It is about having a provider who can assess whether the compound is working, whether the dose is appropriate for the specific injury and patient profile, and whether the response at weeks four and eight warrants continuing, adjusting, or pausing

The researchers also observed that 532 participants with BMI 35 at week 0, who had tolerated their assigned dose of medication, were then escalated to the maximum tolerated dose (9mg or 12mg) for a further 24 weeks