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12,58,59 In a comprehensive systematic review and meta-analysis including more than 34,000 patients with T2DM, semaglutide therapy was not associated with an increased risk of pancreatitis

We emphasize the role of insulin sensitization as a therapeutic goal in type 2 diabetes mellitus

This increase of FFA in the liver and circulation results in hypertriglyceridemia, pronounced in the postprandial period, and fasting dyslipidemia leading to insulin resistance, obesity, and unfavorable changes to the cardiometabolic profile [10, 11]

doi: 10.3322/caac.21660 2 GBD 2019 Colorectal Cancer Collaborators