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The procedure was repeated with the reaction mixture containing solution of enzyme (glutathione transferase (GTs))

As superoxide is subject to efficient dismutation by cellular superoxide dismutases, it is possible that NFT might directly interact with Keap1 to induce the observed release of Nrf2 and its escape from proteasomal degradation

Compound 28 is a new quinoxaline-2,3-dione derivative synthesized from N-[2,3-dioxo-6-(phenylethynyl)-3,4-dihydroquinoxalin-1(2H)-yl] benzamide as a lead structure, which is a competitive GluK3 antagonist with sub-micromolar affinity and unprecedentedly high binding selectivity, with 400-fold higher selectivity for GluK3 than for other cognate receptors, and no agonistic or antagonistic activity in mGluRs isoforms [186]

PMC 2861907

Int J Mol Sci 2022