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In addition, the suppression of EPO on hepcidin expression may be related to the erythroferrone (ERFE) produced by erythroblasts in response to EPO, which could target hepatic BMP/SMAD signaling via preferentially impairing an evolutionarily closely related BMP subgroup of BMP5, BMP6, and BMP7 [5456]

Now that the FDA has put this warning on febuxostat, even in people with kidney abnormality we would be likely to start allopurinol first