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44 The 52-week data from 966 patients with MASH and F1B, F2, or F3 fibrosis in the MAESTRO-NASH trial revealed significant effects of resmetirom on MASH resolution, fibrosis improvement, and LDL cholesterol reduction (NCT03900429), 77 forming the basis for potential FDA approval of resmetirom for MASH treatment

Blend Composition CJC-1295 (No DAC) GHRH Analog 5mg Ipamorelin Ghrelin Agonist 5mg Reference data CJC-1295 + Ipamorelin Blend specifications Composition 5mg CJC-1295 (No DAC) + 5mg Ipamorelin CJC-1295 class Synthetic GHRH(1-29) analogue (modified, No DAC) Ipamorelin class Synthetic pentapeptide GH secretagogue (GHRP) Total amount per vial 10mg co-lyophilized blend Appearance White lyophilized powder Solubility Soluble in bacteriostatic water Purity 99.4% Research applications Where CJC-1295 + Ipamorelin Blend is used in research Areas of study described in the published literature

Some studies indicate that approximately 20-30% of weight loss from GLP-1 therapy may come from lean masssimilar to dietary interventions