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Direct increases in collagen mRNA production occur across the effective concentration range of 0.01 to 100 nanomolar

Recent studies have revealed that SFN regulates fat metabolism both in vivo and in vitro through various mechanisms, including alleviating endoplasmic reticulum stress, inhibiting inflammatory response and improving mitochondrial dysfunction, involving Nrf2/ARE, NF-B, NLRP3 inflammasome, HDAC8-PGC1 axis and other signaling pathways

The positive rate was 100% (9 of 9) in the liraglutide group but just 14.3% (1 of 7) in the control group (Fig

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