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Individual factors affecting medication response Our research and clinical experience show that individual factors can significantly influence your results with semaglutide: Age and sex: Hormonal differences and age-related metabolic changes can affect medication response Medication interactions: Some common medications may reduce effectiveness Genetic factors: Variations in GLP-1 receptors can influence how well your body responds Starting BMI: Those with higher initial BMIs may see larger absolute weight loss Previous weight cycling: A history of yo-yo dieting can affect how our body responds Semaglutide options available in the UK 2025 status How do you maximise the results of semaglutide

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appetite suppression Naltrexone/bupropion (Contrave): Opioid antagonist + antidepressant