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However, in the presence of oxidative or nitrosative stress, GST can form homodimers that alter the reduced states of cysteine residues in its structure, resulting in JNK dissociation from the GSTJNK heterocomplex and causing subsequent activation of the c-Jun protein

Some lean-mass change is expected with any weight loss, but it's largely manageable

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In fact, telling yourself this problem is simply a part of having ME/CFS can be helpful