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Endothelial edema precedes blood-brain barrier breakdown in early time points after experimental focal cerebral ischemia

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To encapsulate, mitophagy is an evolutionarily conserved mechanism that identifies and degrades dysfunctional mitochondria in a timely manner, thereby mitigating oxidative stress and enhancing cellular energy

However, FcRn antagonists with the ability to degrade the receptor, such as observed in vitro for batoclimab [237], could potentially prevent viral infection, and for specifically arteriviruses, it has been shown that orilanolimab can block infection of a range of cell lines [380]