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and 2) enzymes such as FSP1, DHODH, NOS2, MBOAT1/2, and GCH1 produce radical-trapping antioxidants (RTAs, e.g., CoQ10, NO, and BH4), which terminate phospholipid peroxidation to block ferroptosis (38, 6971)

The only GLS inhibitor to have entered clinical trials is commonly referred to as CB-839 or commercially as Telaglenastat

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Three different pH levels were tested in the dissolution flask, which contained 900 ml of dissolving media

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors