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5 Parasite-induced mitochondrial damage mechanisms Parasitic infections, caused by protozoa such as Plasmodium spp., Leishmania spp., Trypanosoma spp., and Toxoplasma gondii , represent a global health challenge, particularly in tropical and subtropical regions

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The disbalance between the inhibited enterocytic influx and unchanged or increased systemic demand may cause specific vulnerability of the gut epithelium to toxic effects of the thiamine-competitive drugs targeting SLC19A3