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Seemingly contradictory, various previous studies on tumor cell lines (38, 39) or murine DCs ( NRF2 and HO-1 upon SFN treatment in both untransformed human T-cells (Supplementary Figure 5A) and prostate cancer PC-3 cells (Supplementary Figure 5B)

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2.7 Single-gene Gene Set Enrichment Analysis and Gene Set Variation Analysis analysis of key genes To explore the potential regulatory mechanisms of key genes in RA, GSEA and GSVA were performed to evaluate the association between key genes and HALLMARK pathways