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Placebo-adjusted increase in heart rate by retatrutide was 5.6bpm in the obesity trial at 48 weeks and 7.5bpm in the diabetes trial after 36 weeks [3]

The decision marks a reversal for Caremark, which last summer became the only major pharmacy benefit manager to exclude Zepbound while continuing to cover rival Novo Nordisks Wegovy

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Preparation The injection site is cleaned, and a topical anesthetic may be applied to minimize discomfort

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