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doi: 10.1016/j.mrfmmm.2004.05.011 138 GoodarziMTNavidiAARezaeiMBabahmadi-RezaeiH

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COPD patients experience a progressive limitation of airflow, arising from two primary pathological processes: remodeling and narrowing of the small airways, and destruction of the lung parenchyma, which results in the loss of alveolar attachments due to emphysema [133]