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A meta-analysis of 8,131 patients with ischemic stroke in which patients with elevated baseline levels of serum UA at the time of stroke onset were found to have better clinical outcomes compared to low serum UA levels (HR, 0.77

This is due to intensive collateral circulation

When the accumulation of ROS exceeds the physiological threshold, it can induce cell apoptosis by activating the caspase pathway, ultimately leading to a reduction in the number of DCs and immune dysfunction (80)

It also shows neuroprotective activity: GHK-Cu reduced oxidative damage markers and improved outcomes in neuronal cell culture models of ischemia

Ghrelin strongly stimulates appetite (hence its role as the hunger hormone) and elevates cortisol and prolactin