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This typically means the first 4 to 8 weeks of treatment, with symptoms peaking around weeks 2 to 4

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However, persistent hiccups lasting more than 48 hours, or hiccups accompanied by vomiting, severe abdominal pain, or signs of obstruction, require medical evaluation to rule out medication intolerance or gastric complications

Hepatoprotective effect of sitagliptin against methotrexate induced liver toxicity