Gene expression analysis in ARPE-19 cells was conducted by amplifying the following genes: SOD2 (protein name: superoxide dismutase 2, mitochondrial), CAT (protein name: catalase), HMOX1 (protein name: heme oxygenase 1), SNAL1 (protein name: Snail Family Transcriptional Repressor 1), ZEB1 (protein name: Zinc finger E-box-binding homeobox 1), TWIST1 (protein name: Twist Family BHLH Transcription Factor 1), VIM (protein name: Vimentin), FN1 (protein name: Fibronectin 1), ACTA2 (protein name: actin alpha 2, smooth muscle) and GAPDH (protein name: glyceraldehyde-3-phosphate dehydrogenase)
Bicknell says an oral formulation of a protein is really exciting from a pharmacological perspective, as well as offering greater accessibility for patients
However, GLP-1s need to be studied more and on a wider scale. Hsiangkuo Yuan, MD, PhD, study co-author and clinical research director at Jefferson Headache Center, agrees, noting that if someone already has obesity and struggles with migraines, taking a GLP-1 may help with both issues
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J Cardiovasc Pharmacol 50:647653 Eason RC, Archer HE, Akhtar S, Bailey CJ (2002) Lipoic acid increases glucose uptake by skeletal muscles of obese-diabetic ob/ob mice
