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doi: 10.1007/s12011-015-0304-9 78 XuXHendryxMLiangXKaheKLiYLuoJ

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in the skeletal muscle of tumor hosts, the levels of phosphorylated Akt were comparable to controls, or even increased, and loss of muscle mass or reduction of fiber size in these mice were not modified by IGF-I gene transfer in the tibialis muscle, while IGF-I gene transfer prevented skeletal muscle atrophy in senescent mice[59]