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33,34 The recent discovery of lymphatic vessels in the brain challenges the paradigm that the CNS is immune-privileged

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The comparison in this article is therefore assembled from separate bodies of evidence human topical cosmetic studies on one side, animal and mechanistic work on the other rather than from a single trial that pits the routes against each other

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Notably, the pH responsiveness of CS further supports its microbiota-regulating effect: Its amino groups impart pH responsiveness, enabling environmentally triggered drug releaseit remains stable in the acidic gastric environment (pH 1.2) to avoid premature degradation, and only dissociates in the neutral-to-weakly alkaline colonic environment (pH 6.0-7.0) where it can directly interact with gut microbes and exert probiotic-enriching effects (187, 188)