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Nonpharmacological and nonsurgical approaches in OA
Pyruvate is metabolized to lactate in the cytosol or converted to acetyl coenzyme A (acetyl-CoA) in the mitochondria to fuel the tricarboxylic acid (TCA) cycle, enhance OXPHOS, and generate ATP [18,19]
Patients should be advised to avoid using GSH with over-the-counter skin lightening creams that may contain mercury
Clinical trial data in the literature examining the biological effects of glutathione intake is fragmented with no clear guidelines for the clinician especially in the management of skin pigmentation issues
Because intracellular cysteine level is usually below 100 M under the physiological conditions 18,19 , the interference of RT signals from cysteine is minimal
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