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In these studies, fetal malformations (primarily craniofacial defects such as cleft palate), limb malformations (ectrodactyly, micromelia, and amelia), rib/vertebral column anomalies, and/or reduced fetal weights were observed at dosages 20 mg/kg in mice (approximately 2 times the MRHD of topiramate in QSYMIA 15 mg/92 mg on a mg/m 2 basis), 20 mg/kg in rats (2 times the MRHD of QSYMIA based on estimated AUC), and 35 mg/kg in rabbits (2 times the MRHD based on estimated AUC)

Weeks 12: 1 mg once weekly (lowest starting dose to improve tolerance and manage side effects

& Imai, S

Amlioration des performances de traitement : Lutilisation du glutathion dans les produits base de nouilles peut rduire le temps de fermentation et de production du pain de moiti, voire dun tiers, par rapport loriginal, tout en amliorant la valeur nutritionnelle et la fonctionnalit des aliments