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Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S -glutathionylation of endothelial nitric oxide synthase: beneficial effects of therapy with the AT1 receptor blocker telmisartan

This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References Kohn, S

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This suggests Dihexa works by restoring deficient synaptic density rather than enhancing already-optimal connectivity, which shifts the dose calculation: someone with pre-existing cognitive deficits may respond to 1mg, while someone with no deficits may see no effect at 5mg