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In patients with high-grade, symptomatic hemorrhoids, surgical hemorrhoidectomy is the most effective modality with the lowest recurrence rates, although it causes more pain than conservative methods

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The soluble epoxide hydrolase inhibitors (sEHi) 12-(3-adamantan-1-yl-ureido)-dodecanoic acid and 14,15-EET preserve the integrity of astrocytes and mitigate excitotoxicity, and their effects are dependent on mGluR5 [32]

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