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Its primary biological functions center on tissue remodeling: it stimulates collagen synthesis (types I and III), promotes decorin production, increases glycosaminoglycan synthesis, and activates metalloproteinase pathways for controlled tissue remodeling

Supports intracellular antioxidant activity

doi:10.1056/NEJMoa030656

Upregulation of cytosolic Ca 2+ activates calcium/calmodulin-dependent protein kinase II (CAMKII), leading to aberrant NF-B signaling and downstream expression of PD-L1 58

Patients with CKD are at dramatically elevated risk of MACE, and progressive kidney disease leads to dialysis, which carries its own enormous cardiovascular burden