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Mechanistic gaps in pathway crosstalk and causality: Current studies have primarily focused on individual pathways (e.g., Nrf2-mediated antioxidant defense and TGF-/SmadHDAC3-driven fibrosis) but lack insights into the core molecular hubs integrating these networks

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Factors such as poor diet, stress, pollution, and chronic illness can exacerbate this depletion

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Following the treatment period, 43% of women who received vitamins E and C experienced reduction in chronic pain, 37% experienced reduction in pain associated with menstruation, and 24% experienced reduction in pain during intercourse compared with the placebo group