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Las estrategias teraputicas actuales suelen combinar tratamientos farmacolgicos (antiepilpticos, antidepresivos, emplastos de lidocana, parches de capsaicina, administracin de toxina botulnica para el dolor localizado) y tratamientos no farmacolgicos (estimulacin elctrica transcutnea o transcraneal) (14) No obstante, hay que sealar que estas clases de medicamentos se asocian a ciertos efectos secundarios notables (somnolencia, mareos, temblores, problemas de coordinacin...) (15-16) Deben introducirse de forma gradual y bajo estrecha supervisin mdica, con un aumento gradual de las dosis a lo largo de varias semanas

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Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy