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Description

Zheng et al., 2020)

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His team sees this pattern often: someone on metformin for insulin resistance, PCOS, or type 2 diabetes, who assumed the exhaustion was just part of trying to lose weight

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Over time, mediators like chronic stress and inconsistent eating patterns sustain it, forming a feedback loop

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[PubMed: 11506989] 189

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What we actually have in humans This is the crux of the clinician dilemma

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