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These activated monocytes enter the CNS via cytokine-induced BBB permeability and develop into macrophage-like cells, reinforcing local inflammation [78]

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5.1 Anti-inflammatory and anti-nociceptive effects Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) play distinct roles in inflammation, with omega-3 PUFAs generally exhibiting anti-inflammatory effects and omega-6 PUFAs tending towards pro-inflammatory actions, through competitive metabolic processes