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When muscle afferents are triggered by muscle fatigue, this triggers the production of heat shock proteins (HSPs) (299)

Phase 2 trial data published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023) reported mean weight reductions of up to approximately 24% over 48 weeks in adults with obesity notably higher than results seen with currently approved agents

Larre et al., 2014)