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While IL-17 alone does not inhibit pigmentation, it significantly amplifies the inhibitory effect of TNF on melanin synthesis through a synergistic interaction (Wang et al., 2013)

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These beneficial effects may be due to the formation of detour circuitswhich encompass spared tissue surrounding the lesionand could reconnect locomotor circuits [69], thus enabling afferent inputs to be processed and conveyed to the cortex [73] and improving spinal reflexes, even below the injury [74]

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