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Multiple in-vitro fibroblast studies and a smaller number of clinical-cosmetic studies report improvements in skin elasticity associated with GHK-Cu exposure, linked to increased elastin synthesis and improved lysyl-oxidase-dependent cross-linking

Astrocyte reactivity is regulated by proinflammatory cytokines and myelin debris

Mutations in the MRP2 gene are associated with DubinJohnson syndrome, a condi- tion due to the lack of hepatobiliary transport of organic anions without bile salts resulting in conjugated hyperbilirubinemia [ 81 , 82 ]

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