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The figure also shows that the selenium-dependent enzyme glutathione peroxidase oxidizes two molecules of glutathione back to GSSG while converting one molecule of hydrogen peroxide (H 2 O 2 ) into two molecules of water (H 2 O)

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doi: 10.1111/j.1365-2249.2009.03956.x

Additionally, trials of oligonucleotide therapeutics and some small-molecule NNMT inhibitors in vitro and in preclinical animal models have validated NNMT as a promising therapeutic target to prevent or treat obesity and related T2D, but currently, clinical trials have not yet been reported