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A secondary effect of this stress is activation of Nrf2 and its target genes resulting in compensatory higher GSH levels and induction of antioxidant genes in the livers of these mice, which makes these livers more resistant to additional acute stress such as APAP toxicity [151]

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3.1.4 Regulate Treg/Th17 balance and reconstruct immune tolerance The imbalance of Treg/Th17 cells is central to the abnormal adaptive immunity in IBD

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In healthy adults the total concentration sits around 200 to 600 pmol/L, but the upper reference limit varies by laboratory and by analytical platform