glp-1 wonder Agonists: Drugs of the 21st Century? The Wonder Years - BOSS

Diabetes Obes Metab 22(12):24872492 Verma S, Bhatta M, Davies M, Deanfield JE, Garvey WT, Jensen C, et al (2023) Effects of once-weekly semaglutide 2.4 mg on C-reactive protein in adults with overweight or obesity (STEP 1, 2, and 3): Exploratory analyses of three randomised, double-blind, placebo-controlled, phase 3 trials

Its primary physiological role involves stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner, which has made GLP-1 receptor agonists valuable therapeutic agents for type 2 diabetes mellitus

Manufactured by BioNebraska, an American biotechnology company, the synthetic GLP-1 was also found to improve both insulin sensitivity and beta cell function without any side effects

Their use grew quickly, and questions remain about how well some risks were explained to patients and doctors

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