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First of all, we should clarify the detailed molecular mechanisms implicated in ferroptosis and gut-joint axis crosstalk, and investigate their synergy with several candidate therapeutic drugs, such as resveratrol, quercetin, etc

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A substantial body of evidence from animal studies [92,93,94,95] and clinical trials [96,97,98,99,100,101] indicates that GLP-1 RAs have a marked effect in ameliorating myocardial ischemia, reducing reperfusion injury, decreasing infarct size, and enhancing cardiac function