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Zhang X., et al., 2020 J Cell Physiol 235 (4):3425-3437

Important Considerations Medical History: Individuals with a history of pancreatitis or certain thyroid cancers (such as medullary thyroid carcinoma) should avoid using semaglutide

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The success of oral semaglutide may ultimately be superseded by small-molecule alternatives that offer comparable efficacy without the absorption limitations inherent to peptide delivery