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That evidence is substantial

Prebiotics modulate the microbiota-gut-brain axis and ameliorate anxiety and depression-like behavior in hfd-fed mice

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There was no additional risk above and beyond the high risk from diabetes.[ref] Risk rises over time: One problem with the epidemiological studies on Lp(a) is that most of them only last for 5 to 10 years, which may not be enough time to really determine causality