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This trial is particularly important because cardiovascular outcome trials (CVOTs) are increasingly required by the FDA for metabolic medications

Pickart L, et al

384:75565 Bhaskaran K, dos-Santos-Silva I, Leon DA, Douglas IJ, Smeeth L (2018) Association of BMI with overall and cause-specific mortality: a population-based cohort study of 36 million adults in the UK

The glucagon arm is the third lever: rather than only reducing energy intake through appetite, glucagon agonism raises energy expenditure and pushes the liver to mobilize stored fat

Gastrointestinal absorption barriers of vitamin B 12 can be avoided by intramuscular injection