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These mechanisms have not been proven yet
Indeed, when the effect of 2APB on drug metabolism was evaluated, it was discovered that 2APB is a P450 inhibitor as directly shown in vitro and observed in vivo when the protection correlated with inhibition of protein adduct formation [155]
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Histone deacetylases in virus-associated cancers
A smaller phase II trial with 35 ES or desmoplastic small round cell tumor patients demonstrated an objective response rate of 6% with single-agent AMG 479 [93]
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