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When GLP-1 receptor activation turns down the volume on wanting, everything pleasurable gets quieter, food, substances, and sex alike

This does not mean the medications are unsafe

67, 76 The role of the proliferative effect on PSCs of liraglutide and the other GPCRs in AP or CP at present is unknown, as is the possibility that prolonged treatment with GLP-1R agonists for diabetes or other diseases, may lead to increased fibrosis due to enhanced PSC growth and activation

Clinical trials show that meaningful weight loss usually begins within the first month, but the full picture depends on your dose, metabolism, and adherence

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