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Serotonin receptors are present on peripheral sensory neurons, and serotonergic signaling plays roles in pain modulation and nerve fiber maintenance

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Immune balance is also influenced by broader systems involved in immune regulation and inflammation, including gut-associated lymphoid tissue (GALT) and the hypothalamic-pituitary-adrenal (HPA) axis, reinforcing the importance of addressing antioxidant capacity as part of a whole-system approach