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While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells

The net reaction is RO +C 6H 7 O (3) 6 RO + C 6 H 7 O 6 ROH + C 6 H 6 O 6 The oxidized forms of ascorbate are relatively unreactive and do not cause cellular damage

Pernicious anemia (lack of intrinsic factor or antibodies against intrinsic factor), atrophic gastritis, and other gastroenteric diseases can cause B12 malabsorption

pH sensitive

Typical Dose: 6001,200 mg 12 daily