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Biochim Biophys Acta (BBA)-Molecular Cell Res (2020) 1867(4):118649

This figure is directly comparable to the performance of tirzepatide (Mounjaro) in the SURMOUNT-1 trial, which showed approximately 20.9% weight loss at 72 weeks, and exceeds the approximately 14.9% achieved by semaglutide alone in STEP 1

Unlike GLP-1 drugs that only work when blood sugar is high, sulfonylureas stimulate insulin release regardless of current blood sugar levels

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