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According to the Merck Manuals, bioavailability is the extent and rate within which an active drug enters systemic circulation after passing through the first-pass metabolism sites, namely, the intestinal wall and liver

By combining all three pathways, retatrutide addresses weight loss from multiple angles: reducing appetite (GLP-1 and GIP), improving metabolic signaling (GIP), and actively increasing calorie burning and fat breakdown (glucagon)

A less common but still valid reason is dose flexibility

While both medications offer distinct and effective pathways to weight loss, their combination introduces potential interactions, particularly concerning gastrointestinal side effects and the absorption of other medications, which are not yet fully understood through direct clinical research

Injectable medications have a faster onset of action and are absorbed more quickly