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46 GIPR is expressed in monocytes that infiltrate vessel walls and differentiate into macrophages and form cells as a component of the atherosclerosis plaque

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Christian Hendershot, an addiction expert who ran the UNC trial and now directs clinical research at the University of Southern California Institute for Addiction Science

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The mechanism is straightforward your immune system has been generating free radicals at high rates, and your antioxidant reserves are lower than usual