Dose adjustments to other diabetes medications may be necessary when starting tirzepatide
Martin trained at the University of California, Irvine Hospital in family medicine, where he treated patients of all ages with obesity, diabetes, thyroid & hormone disorders, high blood pressure, age-related diseases, chronic pain, and autoimmune conditions
Clinical trials vs real-world results What the clinical trials show The landmark SURMOUNT-5 trial published in 2025 compared these medications directly at standard maximum doses: 1 Mounjaro (tirzepatide 15 mg) produced 20.2% average weight loss Wegovy (semaglutide 2.4 mg) produced 13.7% average weight loss The 6.5 percentage point difference was statistically significant This trial used the maximum approved doses at the time (Mounjaro 15 mg, Wegovy 2.4 mg) and lasted 72 weeks
This is a common outcome for patients experiencing rapid fat loss in the breast area
In the US, a months supply of Ozempic or Mounjaro can cost as much as USD 1,000 without insurance
